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Acromegaly associated with enlargement of extraocular recti muscles

This retrospective case review aimed to evaluate the frequency and extent of extraocular muscle enlargement in cases of acromegaly at presentation. All new presentations of acromegaly diagnosis at a single tertiary centre over a five-year period were screened for inclusion....

LSHTM: Skills for Eye Field Research

This course takes place in November/December each year on Thursdays and Fridays over 3 weeks (5 teaching days and one day for the written assessment). All sessions are delivered face-to-face for the whole day (09:30 - 12:45 and 14:00 -...

Cytotoxic effect of voriconazole on human corneal epithelial cells

Voriconazole is a second-generation synthetic derivative of fluconazole with broadened antifungal spectrum. It is becoming the drug of choice for fungal keratitis. Voriconazole eye drops are not available commercially, thus have to be prepared by diluting the intravenous formulation containing...

The long-term effects of AREDS on AMD progression

The Age-Related Eye Disease Study (AREDS) was an 11-centre, double-masked, clinical trial that in 2001 found a high-dose of antioxidant vitamins plus zinc was effective in protecting against progression of age-related macular degeneration (AMD) in patients with moderate to high...

Brolucizumab in age-related macular degeneration, HAWK Study

The aim of the study was to collect additional data on efficacy and safety of brolucizumab 6mg intended for commercialization in age-related macular degeneration (AMD) (with an increase in pH and decrease in polysorbate concentration). The HAWK Study was a...

MPH treatment effect in ADHD on choroidal vascular index

In this study the authors aimed to investigate the choroidal vascular index (CVI) in treatment-free children with ADHD, children regularly taking methylphenidate (MPH) and healthy controls. This was a prospective cross-sectional study of 52 patients with newly diagnosed ADHD, 46...

World-first platform for transparent, fair and equitable use of AI in healthcare

Revolutionary AI platform for detecting diabetic eye disease proven safe for NHS. Researchers have developed the world’s first real-world head-to-head testing platform to determine whether commercial artificial intelligence (AI) algorithms are fit for NHS use to detect disease in a...

Choroidal thickness in ocular sarcoidosis by OCT measurement

This is the first study to evaluate the choroidal thickness in patients with ocular sarcoidosis during the quiescent phase using enhanced depth imaging optical coherence tomography (EDI-OCT) and comparing with normal subjects. Ocular sarcoidosis may affect the choroidal circulation (occlusive...

Effects of blood donation on the physiology of the eye

Hypovolaemia is a state of decreased blood volume, the reduction of which reduces tissue perfusion which may in turn lead to cellular hypoxia and end-organ damage. In blood donation, 500ml of blood is collected in ten minutes. This equates to...

ROP anti-VEGF treatment review

The purpose of this review was to consider data relating to risks and benefits of the use of anti-VEGF treatment for retinopathy of prematurity (ROP) over the past five years of 2015-2020. Ocular benefits include treatment of aggressive posterior ROP,...

Retinoblastoma management update (part 2): treatment, screening and surveillance, long-term follow-up and new developments

Retinoblastoma treatment requires significant multidisciplinary input, but early detection through raising awareness remains key to improving outcomes. In the second article of a two-part series, Manoj Parulekar discusses retinoblastoma management, screening and research. This article has been published in two...

Moorfields Education: Biometry study day April 26

This one-day in-person study day has been designed to meet the training needs of nurses, nursing associates, technicians, and anyone with an interest to improve their knowledge and understanding of biometry and its calculation and reading a biometry report. The...