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Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service

4 August 2021 | | EYE - Paediatrics, EYE - Vitreo-Retinal, EYE - General
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...

100 years of insulin

3 October 2022
*Joint first authors The centenary of the discovery of insulin is a time to celebrate one of the most significant scientific discoveries of the 20th century. Background Before 1923, Type 1 diabetes mellitus [T1DM] resulted in death from severe ketoacidosis...

New UK study finds widespread hidden sensory loss

20 October 2025 | The College of Optometrists, funding, eye health, optometry, sensory loss
One in four over-50s has vision impairment and three quarters have some hearing loss. Groundbreaking research involving eye tests and hearing examinations with more than 500 over-50’s – the first of its kind in the UK – has revealed widespread...

Congenital and paediatric cataract: Advances in diagnosis and management

4 December 2025 | | EYE - Paediatrics, EYE - Cataract
Congenital and paediatric cataracts are relatively rare, although prevalence varies significantly between countries, influenced by factors such as nutrition, immunisation policy and population genetics [1]. In the UK, around 3–4 of every 10,000 babies are born with cataracts. It’s a...

HRH The Duchess of Edinburgh urges action on avoidable sight loss

20 May 2026 | Global, LMIC, Public Health
HRH The Duchess of Edinburgh, Global Ambassador for the International Agency for the Prevention of Blindness (IAPB), today encouraged urgent action to tackle the global crisis of avoidable sight loss. Attending the World Health Assembly for the first time, The...

Feb/Mar 2015 Quiz 1

1 February 2015 | | EYE - Cataract, EYE - Cornea, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal, EYE - General
A 79-year-old male presented to the ophthalmic emergency department with a three week history of left eye pain. He also reported visual deterioration in the left eye over the same period. He suffered from degenerative myopia, with his spectacle prescription...

Chemical injury

6 April 2021 | | EYE - Cornea, EYE - General
You are the on-call ophthalmologist. You receive a call from A&E regarding a 45-year-old man who sustained a chemical injury. He was mixing some cement, when a small amount entered his left eye. He was not wearing any protective goggles....

Demyelinating optic neuropathy

5 June 2023 | | EYE - Neuro-ophthalmology, EYE - General
Introduction Optic neuritis (ON) is an inflammatory process affecting the optic nerve. After glaucoma, it is the most common optic neuropathy affecting patients under the age of 50. The usual presentation of typical ON is unilateral subacute loss of vision...

What’s trending? Dec/Jan 2018

1 December 2017 | | EYE - General
A round-up of the eye related hot topics that have been trending on social media over the last few weeks. #scleratattoo Yes, you read that correctly. Scleral tattoos are a relatively new form of extreme body modification. Oddly enough, ‘sclera...

A case of Miller Fisher Syndrome and bilateral asymmetric globe retraction

1 February 2022 | | EYE - Neuro-ophthalmology, EYE - General
Miller Fisher syndrome (MFS) is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It was first recognised by James Collier in 1932 as a clinical triad of ataxia, areflexia and ophthalmoplegia. Later, it...

A case of ‘60-day glaucoma’

3 April 2023 | | EYE - General
Neovascular glaucoma (NVG) has been called ‘90-’ or ‘100-day glaucoma’ in the past due to its typical development three months after the onset of central retinal vein occlusion (CRVO). In reality, NVG can occur anywhere between two weeks and two...

Dramatic myopic shift due to epithelial basement membrane dystrophy

3 October 2024 | | EYE - Cornea
Epithelial basement membrane dystrophy (EBMD), also known as map-dot-fingerprint dystrophy, is a common anterior corneal disorder affecting approximately 2% of the population [1]. It is characterised by the abnormal maintenance of the basement membrane, resulting in protrusions into the epithelium....