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Inner nuclear layer of the retina showing increase in thickness in diabetic macular oedema

Diabetic retinopathy is one of the leading causes of blindness in the developed world. With optical coherence tomography (OCT), it has become possible to image the retina in vivo and to measure retinal oedema by measuring retinal thickness (RT) with...

Progression of retinitis pigmentosa

This retrospective study evaluates the rate of progression of retinitis pigmentosa (RP) using multimodal imaging, including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and microperimtery (MP). Traditional tests used to evaluate RP, for example, Goldmann visual fields and ERG...

Correlation between aqueous flare and macular microvascular status in diabetes mellitus

The authors report a cross-sectional study which was conducted to investigate the correlation between aqueous flare and macular microvascular status, assessed by optic coherence tomography angiography (OCTA) in diabetes mellitus. Fifty-two diabetic patients with non-proliferative retinopathy, 44 diabetic patients without...

Relating metamorphopsia severity and OCT findings in advanced epiretinal membranes

The authors present the findings of a retrospective study to correlate metamorphopsia and ectopic inner foveal layers (EIFL) or ‘central bouquet’ abnormality (CBA) in patients with advanced stages of epiretinal membrane (ERM) following the new OCT‐based grading scheme as described...

Can retinal layer thickness predict the progression of disability in MS?

This is an observational retrospective cohort study presenting the data of 188 patient diagnoses with multiple sclerosis at two specialist centres. All included patients were adults below the age of 70 years, stable on their disease modifying treatment for at...

Exploring the potential of neurodegenerative disease screening within age-related eye disease research

The authors recruited healthy controls aged between 60 and 75-years-old, previously enrolled into a registry as patients following cataract surgery without age-related macular degeneration (AMD). Exclusion criteria included dense cataract, retinal disease, ocular inflammatory disease, moderate glaucoma, optic neuropathy, cancer,...

Early structural and functional retinal changes in intermittent exotropia

This study aimed to evaluate and compare spectral domain optical coherence tomography (SD OCT) and electrophysiological measures in patients with intermittent exotropia and healthy controls, to outline changes in retinal and optic nerve structure and function. This was a cross-sectional...

LambdaVision aims to refine process for in-space manufacturing of artificial retinas through ISS National Lab-sponsored investigation

Approximately 1.5 million people worldwide are affected by retinitis pigmentosa, a rare genetic disorder that causes vision loss. Currently there is no cure, but researchers from LambdaVision are turning to the International Space Station (ISS) National Laboratory to look for...

The paediatric cataract: an overview of the diagnosis and management

In this second article (see first article here), Samuel Aryee and Rhys Dumont Jones review the challenges involved in managing this condition. Examination and diagnosis Cataracts in children can appear in a variety of forms, each presenting in a different...

The treachery of images – making sense of OCT imaging

In 1929 Belgian surrealist Rene Magritte produced his painting La Trahison des Images. It depicted an old fashioned pipe for smoking tobacco and underneath were the words “ceci n’est pas une pipe”, this is not a pipe. You may wonder...

In conversation with Robert Henderson

Revolutionary eye treatments offer hope for children facing blindness from CLN2 batten disease. Robert Henderson discusses this, and his use of Heidelberg Engineering’s Spectralis device to better combat it. Pioneering research from Great Ormond Street Hospital (GOSH) and the University...

The role of spectral-domain OCT RNFL in revealing a pituitary adenoma with atypical visual fields

Pituitary adenomas classically cause bitemporal hemianopia by compressing the optic chiasm. However, in some cases, the pattern of visual field loss may be atypical and mimic homonymous hemianopia, depending on the direction and extent of tumour expansion. Spectral-domain optical coherence...