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Optic nerve head perfusion response to reduced blood pressure and increased intraocular pressure

The purpose of this prospective study was to test the hypothesis that blood flow autoregulation in the optic nerve head has less reserve to maintain normal blood flow where there is a blood pressure induced decrease in ocular perfusion pressure...

Nicotine accelerates diabetes induced retinal changes

This study investigated the influence of nicotine in an experimentally induced diabetic rat model. They used non-invasive high-resolution spectral domain optical coherence tomography (SD-OCT) imaging to provide quantitative information on the temporal alterations of retinal structures at the micrometer resolution...

OCT imaging of occluded puncta

This is a description of the use of enhanced depth optical coherence tomography (OCT) to see whether a patent ampulla or canaliculus is detectable in patients with absent or occluded puncta. Nine occluded puncta of six patients with epiphora were...

Conjunctival inflammation in glaucoma patients

Numerous studies have demonstrated that topical medications and preservatives used for the management of glaucoma can induce significant histopathologic and inflammatory changes in the ocular surface. This study describes an increased expression of major histocompatibility complex class II antigen HLA-DR,...

Short-term effects of intravitreal bevacizumab on the cornea

Bevacizumab has been extensively used to treat macula oedema and neovascularisation of the retina and it has also been useful in the management of corneal neovascular diseases. This prospective study aimed to provide more information on the effect bevacizumab may...

Vital dyes in ophthalmology

This comprehensive review gives an excellent summary of the uses and properties of the different dyes available to aid better visualisation and diagnoses in ophthalmology. The authors clearly display the pharmacological properties, molecular details, osmolarity and indications in clinical ophthalmology...

Patient-reported outcomes in oculoplastic surgery

This is an important if somewhat difficult to grasp article which tries to formally address the subject of patient-reported outcomes in oculofacial surgery. The authors have conducted an extensive review of the literature searching for instruments (questionnaires) which have been...

Optical quality difference between monofocal and multifocal intraocular lenses

It is well known that multifocal intraocular lenses (IOLs) can generate more than one focus to restore distance and near vision, but patients may experience adverse optical phenomena such as decreased contrast sensitivity and induced glare or halos. The authors...

The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy

The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...

Pterygium ocular surface temperature

This prospective study investigated the ocular surface temperature in patients with pterygia compared to those with dry and healthy eyes respectively. Previous studies have shown that patients with dry eyes show a significant decrease in ocular surface temperature on sustained...

Reduced blood flow and age-related macular degeneration

This was a prospective cross-sectional study assessing changes in blood flow velocity in patients with age-related macular degeneration (AMD) using a retinal function imager. Sixty eyes with wet AMD were compared to 53 control eyes and the average blood flow...

Topical doxycycline for corneal neovascularisation

Six eyes with corneal vascularisation were treated with 1% topical doxycycline, four times a day for three weeks. The patients were reviewed at various intervals over a period of one year. The eyes selected had neovascularisation secondary to a variety...