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Progression in the Early Manifest Glaucoma Trial
The Early Manifest Glaucoma Trial (EMGT) had previously demonstrated without doubt that intraocular pressure reduction decreased the risk of progression in patients with early glaucoma. In this analysis of 306 eyes over eight years from the EMGT, perimetric and optic...
Update on primary angle closure glaucoma
This review article considers primary angle-closure glaucoma which is responsible for half of glaucoma-related blindness worldwide. Angle closure is characterised by appositional contact between the iris and trabecular meshwork. It tends to develop in eyes with shallow anterior chambers, anteriorly...
Prophylaxis for clinical macular oedema after phacoemulsification
The authors report on a retrospective cohort study looking at three different prophylaxis methods for macular oedema after cataract surgery: 1) Topical prednisolone acetate (PA) alone; 2) Topical PA in combination with non-steroidal anti-inflammatory drug (NSAID); 3) Intraoperative subconjunctival injection...
PD-1 and retinal ganglion cell death
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
Effectiveness and Safety of Dexamethasone implants for post surgical macular oedema including Irvine-gass syndrome
This is a retrospective, multicentre, uncontrolled, consecutive case series from Lyon, France between April 20111 to June 2014, with minimum of one year follow-up. The clinical features including the best corrected acuity (BCVA), central subfield macular thickness (CSMT) and intraocular...
A case series of acute visual loss following excessive alcohol and / or drug use
This study presents three cases of so called Saturday night retinopathy, an acute visual loss following intravenous drug abuse and stupor, leading to continuous pressure on the orbit while asleep. All three cases presented with acute vision loss and had...
Binocular summation with low contrast
The magnitude of binocular summation was investigated in normal control subjects using four different letter charts of varying type with fixed and variable contrast levels and spatial frequency to determine which tests most readily reveal binocular summation in normal subjects....
Safety and outcome of microincision vitreous surgery in uveitis
This paper reports the outcomes of microincision vitreous surgery (MIVS) 23G/25G in uveitis of 103 patients (106 eyes) who underwent diagnostic MIVS over a period of four years at the Advanced Eye centre in Chandigarth India. The postoperative evaluation included...
Methotrexate and mycophenolate mofetil for non-infectious uveitis
This is the first reported randomised clinical trial comparing methotrexate versus mycophenolate mofetil (MMF) for the treatment of non-infectious intermediate uveitis, posterior uveitis or panuveitis. To be eligible for recruitment, patients had to be on ≥15mg oral prednisone and demonstrated...
Short-term effects of intravitreal bevacizumab on the cornea
Bevacizumab has been extensively used to treat macula oedema and neovascularisation of the retina and it has also been useful in the management of corneal neovascular diseases. This prospective study aimed to provide more information on the effect bevacizumab may...
Akimba mice, a model of human diabetic retinopathy
Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...
