You searched for "MMC"

334 results found

Chorioretinal atrophy in punctate inner choroidopathy / multifocal choroiditis

This study reported the five-year outcomes of chorioretinal atrophy (CRA) progression in patients with punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) in 45 eyes of 36 patients. The mean age of the cohort of patients was 37 ±13.37 years...

Moorfields cornea focus 2024

The Moorfields cornea focus meeting is a non-promotional meeting supported by an educational grant from Santen UK and organised by Professor Sajjad Ahmad, Consultant Ophthalmic Surgeon at Moorfields Hospital. Each year the meeting focuses on a different topic. Co-chaired by...

Methotrexate and mycophenolate mofetil for non-infectious uveitis

This is the first reported randomised clinical trial comparing methotrexate versus mycophenolate mofetil (MMF) for the treatment of non-infectious intermediate uveitis, posterior uveitis or panuveitis. To be eligible for recruitment, patients had to be on ≥15mg oral prednisone and demonstrated...

Management of restrictive diplopia after ptergium surgery

This single centre retrospective case series included 15 patients with restrictive diplopia after ptergium excision. The mean time from surgery to diplopia was six months and all patients had a moderate limitation of abduction in the operated eye causing an...

Augmented trabeculectomy with mitomycin C in primary congenital glaucoma

This study aimed to determine success of trabeculectomy augmented with mitomycin C (MMC) in children with primary congenital glaucoma (PCG) and document complications of this intervention. Over a two-year period, the authors treated 74 eyes of 42 children with PCG,...

Delayed improvement in Muller’s muscle ptosis surgery

This is a retrospective review of patients undergoing ptosis surgery. The authors had noticed anecdotally that although a posterior approach Muller’s muscle and conjunctival resection (MMCR) appeared to achieve similar results to an anterior approach levator resection (ALR) in the...

RCOphth Back to Basics - Byte sized topics for all

The Royal College of Ophthalmologists Back to Basics - Byte sized topics for all

Using frequency doubling technology perimetry to identify Alzheimer’s disease early

Alzheimer’s disease is widely reported to be associated with deficits in visual function. Visual disturbances include impaired stereopsis, contrast sensitivity and motion detection. Deficits specific to the magnocellular pathway (MGC) have been identified in Alzheimer’s disease. This article compares the...

Ologen Collagen Matrix to treat ocular hypotony after filtration glaucoma surgery

The authors report a retrospective, observational case series of a Japanese cohort. 12 consecutive implantations of ologen in nine eyes of nine subjects (five men, four women; mean age ±SD, 72.1±12.7 years) who underwent subconjunctival implantation of the device to...

Using OCT to screen and monitor Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative illness characterised by progressive decline in cognitive function. AD is the main cause of dementia worldwide. Over recent years researchers have strived to find biomarkers to diagnose AD, particularly in the early stages of...

Comparison of structural and functional features in primary angle closure and open-angle glaucoma

In this large cross-sectional study, differences in structural and functional damage were assessed among patients with primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG) with optical coherence tomography and reliable visual field testing. Two-hundred and eighty-three patients with...

RPTP-σ increases pro-MMP activity in a trabecular meshwork cell line following oxidative stress conditions

This study aims to outline the role of phosphatases in the aqueous drainage system by overexpressing receptor tyrosine phosphatase sigma (RPTP-σ) in a human normal trabecular meshwork cell line and describing its effect on subtypes of matrix metalloproteinases (MMP) and...