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Understanding retinal ciliopathy through Bardet-Biedl syndrome

This is a review article looking at up-to-date understanding and ongoing research in retinal ciliopathies. Syndromic ciliopathies consist of a group of disorders caused by ciliary dysfunction or abnormal ciliogenesis. These disorders have multiorgan involvement in addition to retinal degeneration...

Long-term effect of gene therapy on Leber’s congenital amaurosis

After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...

Comparison of retinal pigment epithelium-choroid graft surgery and anti-VEGF therapy in patients with wet AMD

This was a randomised intervention study in wet AMD patients to investigate benefits of free RPE-choroid graft transplantation surgery versus (continuation of) anti-VEGF treatment. Twenty patients who met the inclusion criteria were subdivided into three subgroups, i.e. RPE tears involving...

Relationship between nocturnal intraocular pressure elevation and diurnal intraocular pressure level in NTG patients

This group studies Korean normo-tension glaucoma (NTG) patients over a 24-hour period to assess if there was a relationship between nocturnal intraocular pressure (IOP) and diurnal IOP. They have previously suggested differences in diurnal IOP may have varying mechanisms of...

Intracameral sodium hyaluronate for postoperative hypotony after Baerveldt glaucoma implant

This is a retrospective study to examine the effect of 0.1ml of sodium intracameral sodium hyaluronate 1.4% (Healon GV – HGV) in patients who had hypotony (IOP<5mmHg) within three months of having a Baerveldt glaucoma implant (BGI) operation. Hypotony is...

Characteristics of limbal lymphatic vasculature on confocal microscopy

This ex vivo study aims to describe the morphological characteristics of the human limbal lymphatic vasculature using confocal microscopy and immunofluorescence. Twelve corneal specimens are obtained from human donor eyes. These corneal buttons are not suitable for transplantation due to...

Incidence of high IOP following corneal collagen cross-linking

This retrospective cohort study examined 405 patients (405 index eyes and 218 untreated fellow eyes) who underwent cross-linking over a 12-year follow-up duration at Duke Eye Center. Preoperative and postoperative intraocular pressure (IOP) measurements were collected at ~1 month, 3...