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γδ T cell depletion does not affect fungal keratitis
Fungal keratitis (FK) is a blinding condition prevalent in agricultural areas of countries such as India and China. The fungus enters the cornea and induces an inflammatory response which leads to tissue damage. Neutrophils are the earliest infiltrating immune cells...
Incidence, microbiological profile and in vitro antimicrobial susceptibility of IK
This is a retrospective single centre study of all patients (with corneal scraping) including their demographic factors, microbiological profiles, and in vitro antibiotic susceptibility of infectious keratitis (IK), studied between 2007 and 2019. The incidence of IK was 34.7/100,000 people...
Insights in resistant diabetic macular oedema
This article gives a bird’s eye review of the different modalities for the treatment of diabetic macular oedema (DME). The debut of anti-VEGFs has brought a paradigm shift in DME management. This treatment has now become a major breakthrough in...Fusarium keratitis in a patient with alcohol dependence
Treatment of fungal keratitis secondary to the Fusarium species remains a challenge. Although relatively more common in warmer climates, this corneal infection is rare in the UK. Most cases have been reported in farmers and are often preceded by trauma....It’s not always GCA
Giant cell arteritis (GCA) is an immune mediated granulomatous inflammatory disease that affects muscular middle or large sized arteries. It is considered as a continuation of polymyalgia rheumatica (PMR) when the severity of the disease has increased. It is the...
Corneal cross-linking for treatment of corneal ulcers
This was an observational cohort study looking at the usefulness of photo activated chromophore for infectious keratitis-corneal collagen cross-linking (PACK-CXL) in reducing the time to heal in suppurative corneal ulcers. This study, conducted in a tertiary care centre in South...
PUK after corneal crosslinking
This retrospective study aimed to report the incidence, characteristics, clinical presentations, risk factors, and the available treatment modalities of sterile peripheral ulcerative keratitis (PUK) post-corneal collagen crosslinking (CXL). In total 771 eyes of 474 patients operated for keratoconus or ectasia...
Use of Leflunomide as a treatment for paediatric chronic uveitis
Leflunomide is a disease modifying anti-rheumatic drug approved for treatment of rheumatoid arthritis and psoriatic arthritis in adult patients. This study reports five illustrative case reports of children using Leflunomide as an adjunct treatment with anti-tumour necrosis factor (TNF) agents...
