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3669 results found

100 years of insulin

*Joint first authors The centenary of the discovery of insulin is a time to celebrate one of the most significant scientific discoveries of the 20th century. Background Before 1923, Type 1 diabetes mellitus [T1DM] resulted in death from severe ketoacidosis...

Prism cover test variances

The purpose was to establish the inter-examiner variability and agreement between more than two examiners assessing children and adult patients. The study involved four experienced examiners. The alternate prism cover test (APCT) was conducted at near and distance in 41...

Consecutive exotropia features

This study sought to detect abnormal scleral attachment with comparison of histopathological findings in consecutive exotropia. The study also considered the success rate of medial rectus resection and advancement, dose response and evaluate potential preoperative factors that might indicate presence...

Normal videonystagmography data

The authors report on the smooth pursuit and saccadic eye movement waveforms elicited from normal patients while viewing standardised calibrated targets. Serial trials were performed on each patient to determine test / retest reliability: nine trials producing 117 results by...

The vitreoretinal priesthood

When I first started doing cataract lists, the consultant at the time, a Mr Brown from Carmarthen, used to say that phacoemulsification was more akin to flying a jet fighter for short dangerous bombing runs than a boring long haul...

Medial rectus inferior half plication surgery for near exotropia

In this study the authors report a relatively new surgical treatment for near exotropia. The study included 17 patients: four with previous surgery and all with medial rectus injection of bupivacaine to reduce the angle of deviation. Treatment involved inferior...

RCT of surgery to correct asymmetrical DVD

This study compared the efficacy of two procedures: (1) bilateral symmetrical anteriorisation of the inferior oblique (AIO) and (2) combined resection and AIO, in cases of asymmetrical dissociated vertical deviation (DVD). This was a prospective randomised controlled trial including 54...

Chloral hydrate sedation

A systematic review of literature sourced from PubMed, EMBASE, ISI, Web of Science, Scopus, CENTRAL, Google Scholar and Trip database to 1 October 2015, about the safety and efficacy of chloral hydrate (CH) by meta-analysis of randomised controlled trials (RCTs)...

Prism adaptation responses for variable distance-near deviation in intermittent exotropia

The purpose of this study was to evaluate the effect of the prism adaptation test (PAT) on angle and distance-near-deviation (DND) in intermittent exotropia (IXT), and determine the frequency of responders and non-responders to PAT. This was a single-centre study...

A closer look at the new wave of glaucoma surgery – radical or old school?

Glaucoma is a challenging condition to treat because the exact pathophysiology remains unclear and the only readily modifiable factor is the intraocular pressure (IOP). Additionally, most glaucoma patients are completely asymptomatic, yet are often subjected to lifelong medical therapy. The...

Chronic lymphocytic leukaemia (CLL) of the lacrimal sac

The authors present a case series of three patients with known CLL, two of which presented with mass and epiphora and one case with epiphora alone. All three patients had initially being diagnosed and were treated for chronic dacryocystitis. Histopathological...

Incomplete teprotumumab treatment for thyroid eye disease

This is a multi-centre retrospective analysis of clinical outcomes in patients who were on teprotumumab for thyroid eye disease but had the usual regime of eight infusions, three weeks apart, interrupted due to COVID-19. Manufacturing was suspended between Dec 2020...