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Effect of voriconazole of vision of healthy volunteers

Voriconazole is a broad spectrum, triazole antifungal agent used for systemic fungal infections. It has a favourable safety profile and is available in both intravenous and oral forms. The commonest adverse drug reactions with voriconazole are changes in visual perception,...

Switchover study from Botox to Xeomin for facial dystonia

This study carried out in the UK compared the clinical effectiveness and efficiency of switching patients from Botox® injections to Xeomin®. This was carried out in 20 essential blepharospasm, 12 hemifacial spasm and six aberrant facial nerve regeneration patients. Patients...

Outcomes for IRS implantation for keratoconus

The authors report visual and topographic outcomes of intracorneal ring segment (ICRS) implantation alone or in combination with corneal cross linking (CXL) and long-term results in halting keratoconus in paediatric patients. This study was a retrospective design including 19 patients...

Management options for microphthalmia with orbital cyst with / without visual potential

The authors present six cases (seven eyes) of congenital microphthalmia and orbital cyst. These cases were newborn mainly with one aged 20 years. There were four females and two males and two of seven eyes had a visual potential of...

Surgery to reduce chin-up abnormal head posture with nystagmus

The authors report the surgical results of six patients with chin up abnormal head posture (AHP) in infantile nystagmus syndrome (INS) where maximal inferior rectus weakening (recession) was undertaken along with superior rectus resection in four of the cases. This...

Visual outcomes and predictors in optic pathway glioma

This is a retrospective study of 60 paediatric optic pathway glioma (OPG) patients (NF1 or sporadic) presenting to Great Ormond Street between 2003-2017. Median follow-up was 82 months. Analysis was divided into best and worst eye vision representing level quality...

Using bupivacaine to the medical rectus in addition to lateral rectus recession for convergence insufficiency type intermittent exotropia

This is a retrospective study of 60 paediatric optic pathway glioma (OPG) patients (NF1 or sporadic) presenting to Great Ormond Street between 2003-2017. Median follow-up was 82 months. Analysis was divided into best and worst eye vision representing level quality...

Post hoc analysis of the CANTREAT randomised trial

CANTREAT, a Canadian multicentre two-year randomised trial compares treat and extend treatment (T&E) relative to the monthly administration of Ranibizumab in nAMD. Two-hundred and eighty-five treatment-naïve patients with nAMD were randomised to receive either a once-monthly dosing or T&E regimen...

How long to wait to refract after instilling cyclo drops for children with brown irides?

This study aimed to assess the time needed for effective cycloplegia after instillation of 1% cyclopentolate drops in children with brown irides. The study recruited 161 consecutive patients aged three to 16 years. All had refraction on arrival, then instillation...

A novel computerised portable pupillometer detects and quantifies relative afferent pupillary defect

We have all had referrals from A&E telling us that a patient can’t see out of one eye. Sleepily we may ask “Is there an relative afferent pupillary defect (RAPD)?” to evaluate the seriousness of the presentation. The response is...