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Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service

4 August 2021 | | EYE - Paediatrics, EYE - Vitreo-Retinal, EYE - General
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...

Comparison of retinal pigment epithelium-choroid graft surgery and anti-VEGF therapy in patients with wet AMD

1 December 2015 | | EYE - Vitreo-Retinal
This was a randomised intervention study in wet AMD patients to investigate benefits of free RPE-choroid graft transplantation surgery versus (continuation of) anti-VEGF treatment. Twenty patients who met the inclusion criteria were subdivided into three subgroups, i.e. RPE tears involving...

RaScaL Study

1 June 2015 | | EYE - Vitreo-Retinal
The RaScaL study was a six month, single-centre, controlled, prospective phase I/II study in which subjects with diabetic macular oedema (DME) and associated peripheral nonperfusion on ultrawide-field fluorescein angiography (UWFA) were randomised to: (1) study arm: ranibizumab (0.5 mg) injection...

Efficacy and safety of intravitreal faricimab in nAMD, DME and RVO

30 January 2025 | | EYE - Vitreo-Retinal
This paper is an analysis of data extracted from 13 eligible studies in the context of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO), collected from systematic literature search of MEDLINE, Embase, and Cochrane...

The Scottish Government Scholarship in Ophthalmology: just a few weeks left to apply!

7 July 2021
A number of scholarships are available for eye healthcare professionals working in Scotland who have been accepted for admission to the online MSc in Primary Care Ophthalmology programme in academic year 2021-2022, thanks to funding from the Scottish Government.

Retinopathy of prematurity treatment in the South West of England: long-term outcomes 1997-2008

1 December 2014 | | EYE - Vitreo-Retinal
Retinopathy of prematurity (ROP) is a condition that affects the developing retinal vascular system of pre-term babies. If left untreated, ROP can lead to severe visual impairment. The severe visual impairment caused by untreated ROP can be prevented by screening...

Well-presented scholarly research work will reduce chances of journal rebuttal

1 April 2018 | | EYE - General
Submitting to an academic journal? Are you aware of the requirements and constraints of relevant copyright laws? Rod McNeil provides a guide for aspiring authors. Getting published in peer-reviewed academic and medical journals is not easy. But careful attention to...

The fragile p-value

5 October 2020 | | EYE - General
Abdus Samad Ansari explores the limitation of the p-value and the application of the fragility index in clinical trials. Clinical trials and tribulations? The restoration of vision or more purely the gift of sight is an aspect of care that...

Shifting the paradigm of managing patients in medical retina: how real-world data can help us to improve clinical practice

1 February 2015 | | EYE - Vitreo-Retinal
The ophthalmic subspecialty of ‘medical retina’ has undergone dramatic changes in recent years. With the introduction of ranibizumab (Lucentis, Novartis), a specialty formerly dominated by laser-based therapies has been transformed to become, in large part, pharmacotherapy-based. To date, these pharmacotherapies...

Real-world experience and outcomes of SLT laser used as a first-line treatment in ocular hypertension patients in a United Kingdom National Health Service setting

3 October 2022 |
The management of raised intraocular pressure (IOP) in the context of ocular hypertension (OHT) and primary open angle glaucoma (POAG) remains a major contributor to the workload of ophthalmology units across the UK. Treatment of these conditions has historically centred...

Idiopathic intracranial hypertension (IIH)

3 June 2021 | | EYE - Neuro-ophthalmology, EYE - General
IIH is a medical condition where the intracranial pressure (ICP) is raised without an obvious cause. The cerebrospinal fluid (CSF) is produced in by the choroid plexus in the lateral ventricles and the roof of the third and fourth ventricles,...

Does vitrectomy increase the risk of glaucoma? A retrospective review from a UK hospital

5 April 2022 | | EYE - Glaucoma, EYE - Vitreo-Retinal, EYE - General
The authors investigate what proportion of patients undergoing pars plana vitrectomy subsequently developed ocular hypertension or a diagnosis of glaucoma. A systematic review carried out in 2017 including seven studies found that there is evidence that pars plana vitrectomy (PPV)...