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Mast cells in Graves’ ophthalmopathy
Graves’ ophthalmopathy (GO) is a potentially sight-threatening ocular disease, occurring in patients with hyperthyroidism due to Graves’ disease. Also known as thyroid-associated ophthalmopathy, GO is characterised by orbital infiltration by immune cells including macrophages, T cells and plasma cells, which...
RTP801 as a neuroprotective and axon regenerative treatment
This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...
Periocular sweat gland carcinomas
This is an interesting review of a rare group of tumours which together comprise the adnexal sweat gland carcinomas. Although there are only 22 patients, this is the largest cohort ever published. The authors summarise the clinical presentation, stage, management...
SLT vs. topical treatment with prostaglandin analogues in the management of PACG
Selective laser trabeculoplasty (SLT) has been shown to be useful in the management of primary open angle glaucoma (POAG), but its use in primary angle closure (PAC) / primary angle closure glaucoma (PACG) has yet to be validated. Narayanaswamy et...
Thrombophilia in patients with retinal vein occlusion
The authors present a retrospective study of the prevalence of thrombophilia in patients with retinal vein occlusion. The study cohort included 88 patients with central retinal vein occlusion (CRVO), 51 patients with branch retinal vein occlusion (BRVO) and 40 controls....
Using frequency doubling technology perimetry to identify Alzheimer’s disease early
Alzheimer’s disease is widely reported to be associated with deficits in visual function. Visual disturbances include impaired stereopsis, contrast sensitivity and motion detection. Deficits specific to the magnocellular pathway (MGC) have been identified in Alzheimer’s disease. This article compares the...
Inflammatory macular holes
The authors present a case of closure of a full thickness macular hole in a patient with Behçet’s disease, without surgery. The 23-year-old male they describe presented with a history of recurrent oral aphthous ulcers and a genital ulcer. Ocular...
Cavernous sinus thrombosis and orbital cellulitis
This is a report of six cases of combined orbital cellulitis and infective cavernous sinus thrombosis, with a literature review. The average age was 39 years, four were male and two were intravenous drug users. All had sinusitis, usually involving...
Atrophy and anti-VEGF
The aim of this study was to investigate treatment factors, along with ocular and systemic factors for their association with macular atrophy (MA) incidence in eyes with neovascular age-related macular degeneration (nAMD) treated with anti-VEGF aflibercept or ranibizumab according to...
Injection of methotrexate into silicone oil-filled eyes for grade C PVR
Methotrexate (MTX) is an antineoplastic antimetabolite with immunosuppressant properties. Folate antagonism is known to contribute to the antiproliferative effects of MTX, and release of adenosine from cells and inhibition of polyamines may explain its anti-inflammatory effects. These activities contribute to...
Microvascular disease in Alport syndrome
The authors present the findings of a retrospective case-control observational study on increased microvascular disease in individuals with Alport syndrome recruited over a 21-year period. They recruited 28 males and 28 females with X-linked Alport syndrome (XLAS) and eight men...
