You searched for "tumour"
Germline mutation risk in solitary unilateral retinoblastoma
This study aimed to determine the true risk for germline mutation in a child presenting with solitary unilateral RB and whether this risk differs by age at presentation. This was a retrospective review of 482 cases from 1972-2020. Age groups...Retinoblastoma management update (part 1): clinical features, diagnosis and genetics
The first of a two part series, this article will discuss the clinical features, diagnosis and genetic aspects of retinoblastoma. Manoj Parulekar is based at Birmingham Children’s Hospital, one of the two designated national retinoblastoma and paediatric ocular oncology treatment...
Practice patterns of uveal melanoma management with Iodine-125 brachytherapy
With the 2006 Collaborative Ocular Melanoma Study Group (COMS) study demonstrating no difference in survival outcomes for participants randomised to either iodine-125 brachytherapy or enucleation, the majority of primary uveal melanomas in the United States are now treated with brachytherapy....Retinoblastoma management update (part 2): treatment, screening and surveillance, long-term follow-up and new developments
Retinoblastoma treatment requires significant multidisciplinary input, but early detection through raising awareness remains key to improving outcomes. In the second article of a two-part series, Manoj Parulekar discusses retinoblastoma management, screening and research. This article has been published in two...
Hidden spread of sebaceous cell carcinoma
This was a review of 29 patients who had undergone orbital exenteration for sebaceous cell carcinoma. Prompted by the increasing use of topical treatments for intraepithelial disease, the authors were keen to discover the frequency of spread of tumour cells...
Conjunctival mapping biopsies in sebaceous carcinoma
This is a retrospective review of conjunctival mapping biopsies in patients with periocular sebaceous cell carcinoma. The authors reviewed the biopsy technique and outcomes of 45 patients who had mapping biopsies performed over a 25-year period. A total of 429...
Histopathology-guided management of ocular surface squamous neoplasia (OSSN) with corneal stromal or scleral invasion using ruthenium-106 plaque brachytherapy
This is a retrospective interventional consecutive case series of 42 eyes of 42 patients with OSSN with histopathologically proven corneal stromal and / or scleral invasion following excision biopsy. The mean tumour basal diameter was 9.3mm and thickness of 3.1mm...
MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
An unusual case of sellar chondroma
A single case of chondrogenic neoplasm arising from the base of the skull is presented and discussed. These benign and slow growing tumours in the sellar region are extremely rare and as such this article provides a useful insight and...
Radiologic characteristics of cavernous venous malformations
This study is a retrospective review of cases with a preoperative radiologic diagnosis of cavernous venous malformations (CVMs) over 30 years. The aim of this study was to define imaging characteristics of CVMs, which will help differentiate these lesions from...
