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119 results found

Control of bleeding with diabetic vitrectomy under air

1 August 2019 | | Retina / Uvea / Vitreous | Air-perfused membrane dissection, fibrovascular membrane, proliferative diabetic retinopathy, vitrectomy
The authors describe a modified diabetic vitrectomy using continuous air infusion in diabetic eyes with severe fibrovascular proliferation. In their case series of 25 eyes (20 patients), intravitreal bevacizumab (1.25mg) was used one week prior to surgery. Fifteen eyes had...

Possible mechanism for infant development of secondary glaucoma

9 August 2023 | | Paediatric Ophthalmology / Strabismus
The authors consider published evidence with regard to potential causative mechanisms for secondary glaucoma that follows infant lensectomy. They review clinical and laboratory studies. The mechanism they propose is that the original lensectomy surgery releases immature anterior lens cells into...

MicroRNA inhibits corneal neovascularisation

1 August 2018 | | Cornea / External Eye Disease | Biomechanical stress, Corneal epithelium, MicroRNA-204, Neovascularization, VEGF, VEGFR2
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...

The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy

1 August 2018 | | Retina / Uvea / Vitreous | Everolimus, mammalian target of rapamycin (mTOR), proliferative vitreoretinopathy, retinal detachment, ribosomal protein S6 (RPS6)
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...

Aflibercept for the treatment of neovascular glaucoma

1 April 2016 | | Glaucoma | glaucoma, intraocular pressure, neovascularization, vascular endothelial growth factor
The aim of this study was to investigate initial results regarding the treatment of neovascular glaucoma (NVG) with intravitreal aflibercept. NVG is classified into stages 0-3. In stages 1 and 2, abnormal vessel proliferation is seen with or without elevated...

Differential inhibition of EAU by CTLA4 and IL-6

1 February 2016 | | Retina / Uvea / Vitreous | Biologic, CTLA4, Cytokine, Experimental autoimmune uveitis, T cell, Uveitis
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...

Sexually transmitted conjunctivitis – the REALLY sticky eye

5 October 2020 | | Ophthalmology, Cornea / External Eye Disease
Let’s face it, patients with conjunctivitis don’t always produce the most stimulating consultations and most of the time we can manage them in auto-pilot. The prospect of delving into such a patient’s sexual history is not overly appealing, but this...

Initiatives in macular service provision

1 December 2015 | | Retina / Uvea / Vitreous
A report from Monitor in October 2015 identifies good practices that will realise most of the potential productivity gain in elective care available to NHS hospitals. These include: stratifying patients by risk and creating low-complexity pathways for lower-risk patients (tailoring...

Ophthalmic mentors: In conversation with Professor Harminder Dua

1 October 2014 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
In the first of a series of interviews with key figures in the world of ophthalmology, Eye News speaks to Professor Harminder Dua about the future of clinical academia, his recent College presidency and Dua’s Layer. Professor Harminder Dua is...

Fight for Sight to maximise impact by funding solutions-focused research in priority eye conditions

1 August 2018 | | Ophthalmology
Fight for Sight aims to stop sight loss by funding pioneering research. Rod McNeil takes a look at the Primer Fellowship Awards programme, which provides funding for up to £60,000 for individuals to undertake vision-related research for one year. Among...

Retinoblastoma – the challenges of a rare cancer and the role of international partnerships

4 October 2023 | | Paediatric Ophthalmology / Strabismus
Introduction: the global challenge The global burden of retinoblastoma (Rb) is one in 15,000-18,000 live births, which equates to 8000 new cases worldwide each year. The global disparities in Rb outcome represent a paradigm of health inequality worldwide [1]. In...

Across the globe and into the world of international eye grading

4 October 2023 | | Imaging
Decades have passed and the influence of analysing fundus images by grading consultants and retinal image specialists has grown worldwide. Their job is to specialise in assessing hundreds of diagnosed eye disease disorders and to read thousands of eye images,...