You searched for "epithelial"
Resurfacing the ocular surface
The ocular surface (OS) is an anatomical and functional unit made of the tear film, the conjunctival, limbal and corneal epithelium, the lacrimal, mucous and meibomian glands and the lids and blink reflex. The tear film is composed of a...
Ranibizumab for the treatment of age-related macular degeneration
This multicentre randomised prospective open label study compared 0.5 versus 2mg of ranibizumab in patients with submacular retinal pigment epithelial (RPE) detachment due to age-related macular degeneration. Four treatment regimens were used for the two strengths either monthly for 12...Quiz Feb/Mar 2020
History A 92-year-old female patient was referred for a three-month history of a left conjunctival growth with ocular irritation. Her past medical history included: hypertension, back pain and osteoarthritis, all of which were controlled by medication. On examination: vision in...Anaesthetic drops abuse
A 67-year-old retired female nurse presented with persistent, bilateral, non-healing (>6 weeks) corneal ulcers and stromal ring infiltrates (Figures 1 and 2). The epithelial defects were the result of chemical burns caused by her contact lenses which had been stored...
Dacryocystosclerotherapy as an alternative to dacryocystectomy
In this article, the authors evaluate the role of sclerosing agents in dacryocystosclerotherapy (DCST) and aim to see whether it is an alternative to dacryocystectomy (DCT) in a specific group of patients. Thirteen lacrimal drainage systems of 10 patients with...
Conjunctival inflammation in glaucoma patients
Numerous studies have demonstrated that topical medications and preservatives used for the management of glaucoma can induce significant histopathologic and inflammatory changes in the ocular surface. This study describes an increased expression of major histocompatibility complex class II antigen HLA-DR,...
OCTA and pigment epithelium detachments
Yannuzzi et al. report on their study aiming to evaluate the ability of optical coherence tomography angiography (OCTA) to differentiate vascularised from nonvascularised pigment epithelium detachments (PEDs) using conventional imaging techniques, including fundus fluorescein angiography (FFA) and indocyanine green (ICG),...
Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...
RPE tears after intravitreal Lucentis
The current hypothesis regarding retinal pigment epithelium (RPE) tears is the contraction and fibrosis in choroidal neovascularisation (CNV) tissue after anti-VEGF therapy can induce rips in the overlying RPE. This South Korean study aimed to identify the association between RPE...
What about the children? Cornea cross-linking for children with keratoconus
Keratoconus can behave more aggressively in paediatric than in adult patients. Collagen cross-linking has been shown to slow the progression of keratoconus in adults. This systematic review determined the effectiveness of corneal collagen cross-linking (CXL) in children. For this study,...
Complement Factor H and Factor H-Like protein are expressed in human RPE cells
The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...
