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The global burden of age-related macular degeneration
Age-related macular degeneration (AMD) is the third leading cause of blindness (behind cataract and refractive error). The authors present the results of the Global Burden of Disease (GBD) 2015 study, which included 195 countries. The disability-adjusted life years (DALY) due...
Intraocular pressure reduction after cataract surgery
Several studies have shown the efficacy of cataract surgery in lowering intraocular pressure (IOP), especially in angle closure glaucoma compared to open angle. A total of 156 eyes of 109 patients (without glaucoma or with medically controlled glaucoma) were included....
Exposure to atomic bomb radiation and age-related macular degeneration in later life
This paper is one of the outcomes of the Adult Health Study; a cohort study of the atomic bomb survivors of Hiroshima-Nagasaki in Japan. It investigates the proposed association between pasty radiation exposure early in life and the presence of...
ABCA1 mediates lipid efflux in the retina
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. There are two forms of AMD, dry and wet, the latter so named because of the presence of choroidal neovascularisation. Both forms lead to retinal pigment...
CD40L activation of human RPE cells
Age-related macular degeneration (AMD) is the leading cause of reduced visual acuity in the elderly worldwide. The risk factors involved in AMD include smoking and diet, while genetics have been shown to have a significant role. Recently a link between...More sensitive visual acuity test for age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. Primarily associated with ageing, genetic factors and lifestyle choices such as smoking also play a contributory role. Patients with early AMD, characterised by the development of...
Changes in drusen and retinal layer volumes prior to CNV development
This retrospective longitudinal study looked at patients with wet age-related macular degeneration (AMD) in one eye who subsequently developed wet AMD in the fellow eye. The aim was to discover whether drusen characteristics or volumes of retinal layers correlate with...
Complement factor B polymorphism and the phenotype of early age-related macular degeneration
The relationship between complement factor H (CFH) and age-related macular degeneration (AMD) is very well known, but other genetic polymorphisms relating to AMD are more poorly understood. This study was designed to investigate the relationship between complement factor B (CFB)...
Complement Factor H and Factor H-Like protein are expressed in human RPE cells
The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...
The rarebit vision test for macular conditions
Rarebit testing is used to measure low degrees of neuro-visual damage and is available for free on the internet. It consists of a fixed bright light dot presented on a black background. During testing it is presented briefly at different...
